Essentials: Timing Light for Better Sleep, Energy & Mood | Dr. Samer Hattar

[Andrew Huberman]
Welcome to Huberman Lab Essentials, where we revisit past episodes for the most potent and actionable science-based tools for mental health, physical health, and performance. I'm Andrew Huberman, and I'm a professor of neurobiology and ophthalmology at Stanford School of Medicine. Today, I have the pleasure of introducing Dr. Samer Hattar as my guest on the Huberman Lab Podcast. And now, my conversation with Dr. Samer Hattar. Samer, thanks for sitting down with me.

[Samer Hattar]
My pleasure.

[Andrew Huberman]
You are best known in scientific circles for your work on how light impacts mood, learning, feeding, hunger, sleep, and these sorts of topics. So, maybe you could just wade us into what the relationship is between light and these things like mood and hunger, et cetera.

[Samer Hattar]
Sure. So, I mean, you do appreciate the effect of light for vision. So, when you wake up in a beautiful area, beautiful ocean, light is essential. The sunrise, the sunset. So, that's your conscious perception of light. But light has a completely different aspect that is independent of conscious vision, and that's how it regulates many important functions in your body. I think the best that is well studied and well known is your circadian clock. And the word "circadian" comes from the word "circa," which is approximate, and "dien" is day, so it's an approximate day. Why is it an approximate day? Because if I put you or any other human being who have a normal circadian clock in a constant conditions, with no information about feeding time, about sleep time, about what time it is outside, you still have a daily rhythm, but it's not exactly 24 hours. So, it will shift out of the solar day because it's not exactly 24 hours, and hence the name "circadian".

[Andrew Huberman]
How does that rhythm show up in the tissues of our body?

[Samer Hattar]
It shows up at every level that we know and we studied. It shows up at the level of the cell, it shows up at the level of the tissue, and it shows up at your behavior. The most obvious for you is your sleep-wake cycle. You sleep and, uh, you're awake and sleep at the 24-hour rhythms. The period length of the sleep rhythm on average is 24.2 hours, so you'll be drifting .2 hours every day out of the solar day if you don't get the sunlight.

[Andrew Huberman]
Huh.

[Samer Hattar]
So, this, the sunlight adjusts that approximate day to an exact day, so now your behavior is adjusted to the light-dark environment or the solar day. It's part of the brain that is not consciously driven, so you actually do not know when it happens or when it doesn't happen. And that what we'll get into when I tell you why light affects your mood and why sometimes people don't know how to deal with light to improve their mood, for example.

[Andrew Huberman]
What's the relevance? I mean, why should we care about that short difference?

[Samer Hattar]
So, let's do the math. If you shift out .2 hours a day, in five days, you're shifting out one hour. So, you're literally one hour off in your social behavior in five days. In 10 days, you're two hours off. And if you're an organism that is living in the wild, shifting out of the right phase of the cycle, you could either miss food or you could become food. So, it's really essential for survival. I think it's one of the strongest aspect of survival for animals to have the anticipation and the adjustment to the solar cycle.

[Andrew Huberman]
What is the, the machinery that allows that to happen? And w- how does that machinery work?

[Samer Hattar]
Yeah. So, we know, we knew that in mammals, including us, we are mammals, humans, that the eyes are required for this function. So, if humans are born without eyes or the optic nerves are damaged, humans are not able to adjust to the solar cycle. So, we know that the eyes are required. In the human retinas, there are two types of photoreceptors. They are called rods and cones because of their shapes. And these rods and cones simply take the photon energy, which light is made of, and they change it in a way to an electrical signal that allow us to build the image of the environment in our cortices. However, people have found, including me with the work of David Berson and Ignacio Provencio, that there's a subset of ganglion cells. The ganglion cells are the cells that leave the retina, their axon leave the retina, and project to the brain. So, these were thought to only relay rod and cone information from the light environment to the brain. We found that a small subset of these ganglion cells are themselves photoreceptors that were completely missed in the retina. And these are the photoreceptors that relay light environment subconsciously to the areas in the brain that have and house the circadian clock or the circadian pacemaker which adjust all the clocks in our bodies to the central brain clock that allows them to entrain to the 24-hour light-dark cycle.

[Andrew Huberman]
So, these are cells that connect the eye and the brain that behave like photoreceptors, essentially.

[Samer Hattar]
Right.

[Andrew Huberman]
I think, um, it's worth mentioning now that, uh, people who are pattern vision blind, so people who cannot see but have eyes, many of them still have these cells, these melanopsin intrinsically photosensitive cells, and can, uh, essentially match or entrain, as we say, onto the, uh, light-dark cycle.

[Samer Hattar]
In fact, they possibly have no problems in circadian photoentrainment. They'll have normal sleep-wake cycle.

[Andrew Huberman]
But they're totally blind?

[Samer Hattar]
But they are totally image blind. And what's really interesting is that... And this story I heard from Chuck Czeisler, so I'll give him credit. That some of these people who are image blind, usually they get dry eyes and they give them a lot of pain. And doctors used to think, "Oh, since they are image blind and they're getting dry eye, why don't you just remove their eyes? They're not using them anymore." And the minute they would remove their eyes, they start having cyclical sleep problems, indicating that now they are not entraining to the light-dark cycle and are having cyclical jet lags when their clock shifts through the light-dark cycle.

[Andrew Huberman]
That's really interesting, and, uh, I hear from a number of blind people. A lot of them have issues with sleep, I think, in part because they don't realize that they too need to see light at particular times of day or night in order to match their-

[Samer Hattar]
Absolutely

[Andrew Huberman]
... their schedule.

[Samer Hattar]
Absolutely.

[Andrew Huberman]
What is the proper way to interact with light in the first...... part of the day.

[Samer Hattar]
Honestly, I think the easiest thing is waking up. Get as much light as you can.

[Andrew Huberman]
Into your eyes?

[Samer Hattar]
Yeah, it's really nice. Your system is primed. If you're entrained, it's primed to get light. The sun should be out. Even when it's cloudy, you're going to get enough intensity to help you adjust your cycle to the day night cycle.

[Andrew Huberman]
These are general rules of thumb, but-

[Samer Hattar]
Absolutely

[Andrew Huberman]
... how long do you recommend people go outside?

[Samer Hattar]
So, if you do it daily, I would say 15 minutes. If you don't do it daily, you may want to increase it. You do it more, it doesn't hurt. And I'll tell you, if you're sensitive, don't- you don't even have to go in the sun. You could be in the shade. There's going to be so many photons out there in the shade. It's going to be perfect.

[Andrew Huberman]
Okay. And if, um, for some reason one finds themself very far north and it's very, very dense, uh, cloud cover, how long and at what point should somebody consider using an artificial light source to mimic the sunlight?

[Samer Hattar]
Yeah. Honestly, this is where we don't have a lot of information still, because this is where we're going to discuss this maybe in more detail, that if you put humans in artificial conditions, the circadian system is very sensitive to light. But in reality, in the real environment, light also is affecting other aspects that are independent of the setting of the circadian pacemaker.

[Andrew Huberman]
Okay.

[Samer Hattar]
And these which we call the direct effect of light on mood, for example. So, that is very hard to figure out what intensity you need to use. And we haven't done enough experiments, because the system has been discovered just recently.

[Andrew Huberman]
Mm-hmm.

[Samer Hattar]
But yeah, I mean, if you're... Honestly, if you're that far north and you're in the winter and you want to get- make sure you don't... Use these light boxes. I, I would suggest that, personally.

[Andrew Huberman]
Okay, so I think we've, um, have nailed down that first part of the day. Basically, it's get 10 to 30 minutes, depending on how bright it is, and try and do that as r- as often as possible to give the system a regular s-

[Samer Hattar]
Daily is the best. This system is really about... And, and you'll see that even for the effect on depression, it's about multiple days is this... So, you don't have to worry if you missed it one day. You know, stay longer if you want. But if you're in a hurry and you want to do other stuff, that's a great recommendation.

[Andrew Huberman]
Mm-hmm. So, you might want to compensate with some extra time if you miss a day or two.

[Samer Hattar]
Absolutely.

[Andrew Huberman]
I've heard you say before, it's entirely possible to get severely jet lagged without traveling.

[Samer Hattar]
Absolutely.

[Andrew Huberman]
Simply by staying in, being on your phone too much-

[Samer Hattar]
Absolutely

[Andrew Huberman]
... not getting the sunlight.

[Samer Hattar]
And you saw this during the pandemic.

[Andrew Huberman]
Right.

[Samer Hattar]
A lot of people mentioned that their sleep wake cycles suffered a lot. Uh, because if you're not going out and if you're staying at home and you don't have big windows and you're waking late, waking up late, and then you're using very bright light 'til late at night, your body's gonna shift. And now, your day is gonna start, instead of like really when the sun comes up, let's say, at 6 o'clock in the morning, it's gonna... So, your day is gonna start at 11 o'clock in the morning. That's what your body's gonna think is the beginning of the day. So, then you're not going to be able to sleep at 10 o'clock at night, because now that's really... For y- for your body, it's completely different timing.

[Andrew Huberman]
There is this idea of chronotypes. That we all each intrinsically have a, a best rhythm of either being a morning person, uh, you called yourself an early person, or a night owl, or more of a kind of standard, you know, to bed around 10:30, up around 7:00 type, um, thing. And the f- and I think there are now good data, correct me if I'm wrong, from the National Institutes of Mental Health and elsewhere showing that the more we deviate from that intrinsic rhythm, the more mental health issues and physical health issues start to crop up.

[Samer Hattar]
So, there is great data on this, and there is couple of things that complicate this. The first is, the people who usually are late-

[Andrew Huberman]
What, what do you mean?

[Samer Hattar]
That means-

[Andrew Huberman]
People that wake up late and go to sleep late?

[Samer Hattar]
Go to sleep late and wake up late, they u- they have an overwhelmingly higher level of depression, because human notice that people who go to sleep early and wake up early, they do better in life. They noticed that.

[Andrew Huberman]
They just perform better.

[Samer Hattar]
They perform... But the question is, is, is that intrinsic to the system or is that society? Because societies start things usually early or late. That's a hard question to answer.

[Andrew Huberman]
We discriminate against late risers.

[Samer Hattar]
We... In a way, we discriminate. And I'm not so sure that the circadian system is that variable in the human population. I mean, clearly there are maybe some genetic factors that make a small percentage of like everything with a bell shape. But I think most of the time, the light environment may play a role. And once, as we've- as we've talked about, this is a long-term effect of light. Once you get into a rhythm, it's hard to break out of that rhythm, because if you start sleeping late and waking up late, you're not getting the morning sunlight.

[Andrew Huberman]
Right.

[Samer Hattar]
And so, you, you're just gonna be late.

[Andrew Huberman]
It seems to me is the case is that the only way to really know if you're meant to be an early bird, as they call it, an early person or a late person, or somewhere in between, is to get morning sunlight and figure out whether or not that makes you feel better. So, what should people do in the a- afternoon/evening time, in terms of their light viewing behavior?

[Samer Hattar]
I mean, the best thing to do is to let the natural light creep in, into darkness, right? That would be the best. But clearly, that would be inefficient. You, you wanna go home, you wanna read, you wanna talk to your kids, you wanna talk to your family. So, I think, you know, it's nice to extend the day. I don't think that's wrong, if you somehow can block that light from affecting your circadian clock.

[Andrew Huberman]
You do keep your home quite dim to dark at night.

[Samer Hattar]
Yeah. I am an extreme, but I measured it for myself and I asked Reju, my wife, if she's okay with it. She also liked the dimness. Both of us can see well in, in dim conditions. But I think you have to measure it for yourself. You really have to do... It's a very simple experiment. Just try to dim the light as much as you can. I, I call it the minimum amount of light you require to see comfortably. You know, use red light that is very dim if you want to keep the room for sleeping. R- red light that is very dim has very small effect on, on, on circadian clock. And below 10 lux of red light literally doesn't affect sleep at all. So, there are ways to do it.

[Andrew Huberman]
I've seen you check your phone after dark-

[Samer Hattar]
Mm-hmm

[Andrew Huberman]
... once or twice. Um, and you did it by sort of...... pointing your phone away from you, right?

[Samer Hattar]
Exactly. Yeah.

[Andrew Huberman]
It actually makes sense that, you know, if you shine a flashlight in your eye, it's much brighter than if you shine a flashlight on the ground.

[Samer Hattar]
Light only go in direct line, so if you just look on the side, most of the light is going to go this way and you're only seeing this.

[Andrew Huberman]
Yeah.

[Samer Hattar]
And, and even when I check sometimes, I check it so fast and switch it off so fast. So ideally I should not check iPhones and iPads. I don't use iPad at night because it's hard to lower it enough 'cause it's, uh, huge. But even my iPhone, I try not to use it at night.

[Andrew Huberman]
You had a, what I consider absolutely landmark beautiful paper published in Nature a few years ago, showing that if you disrupt the exposure to light or the timing of the exposure to light, that there are dramatic effects on the stress system and on the learning and memory system. So, if I interpret that correctly, that could mean that when we view light and how much light could make us feel happier or less happy or even depressed, stressed, learning, et cetera.

[Samer Hattar]
Bingo. Independent-

[Andrew Huberman]
Even if we're sleeping and waking up at the appropriate times.

[Samer Hattar]
Bingo. I mean, eventually, because we're talking about the whole system, eventually when you start having the other problems, you also develop sleep problems. But you're absolutely right. And in fact now research from Diego Fernandez in the lab ha- have found that now we know that they actually require different brain regions. So, we don't only have a theory, we don't only have a light environment that show they can be dissociated, we know that they use completely different brain regions. So, the SCN that I told you about earlier, the place where the central pacemaker is, the one that receives direct input from the retina through the ipRCGs to adjust your circadian clock is not the area that receives the light input for mood regulation. It's a completely different brain region. And what's really amazing, this region also receives direct input from the ipRCGs but projects to areas in the brain that are known to regulate mood, including the ventral medial prefrontal c- prefrontal cortex, which has been studied for many years to be impacted in a human depression. So just by, by this amazing serendipity to find that a region that is so deep in the advanced brain, like the me- the prefrontal cortex is your executive brain, one of the most elaborated in humans, to see that they receive input from these ancient photoreceptor was stunning to us.

[Andrew Huberman]
How does that finding inform daily protocols for you or for other people?

[Samer Hattar]
So that's why we came up with the tripartite model because as a circadian biologist, I only thought of light through the circadian clock affecting behavior. As a sleep biologist, they only thought of the homeostatic drive affecting sleep, affecting behavior. And for people who study light for vision and other, um, they thought only of the environmental input. But now if you put them all together, you get with this tripartite model where it's really mind-boggling and it makes so much sense. The organism doesn't want to depend on a single component, but if you could incorporate these three together, you could have a beautiful system that is well-adapted. So, let me tell you the sleep-wake cycle, right? So, we know there is a homeostatic drive to affect sleep. You've had beautiful talks about that.

[Andrew Huberman]
Which is basically the longer you're awake-

[Samer Hattar]
The more you're awake, the more you sleep

[Andrew Huberman]
... the more you want to be asleep. Yeah.

[Samer Hattar]
So that's your homeostatic drive. We've talked about the circadian influence of sleep and the fact that light-dark cycle affect the circadian system, which eventually affects sleep. So these two components are well-understood. Now, the third factor is your direct light or environmental input. How much stress, how much light you get from there also can highly impact sleep. So even if you have a good circadian and homeostatic drive, if you're getting r- light at the wrong time of the day or if you're being stressed and thinking at the... then your sleep's going to suffer. So you have to think of the three together to have a beautiful sleep-wake cycle.

[Andrew Huberman]
Let's talk about food and eating and appetite.

[Andrew Huberman]
You had yet another, uh, yes, I, I greatly admire your, your success in th- in this way, yet another incredible discovery showing that there are directs of, direct, excuse me, effects of light on appetite and feeding behavior. So, for somebody who's interested in affecting their eating behavior, how should they use light in order to adjust their eating behavior?

[Samer Hattar]
Right. So now that I've told you about all these interaction between the different inputs to the circadian clock, just you think about it as an engineer, what would be the best thing? The best thing is to know when your food times happen in the day, when should you get light, and where is your circad- when is your circadian clock in your system, right? So, if you eat at very specific times of the day, that's another signal that is telling your body, your clock, "You're in a certain time of the day." So if you're having lunch at the correct time every day and you're getting bright light, now you have two systems that are informing your clock. Your clock is going to be better.

[Andrew Huberman]
So regular mealtimes?

[Samer Hattar]
Regular mealtimes that fit your circadian clock. So, and in fact, if you do that, wh- when I started doing this and it helped me lose weight, is that I'm exposing myself to the right amount of light-dark cycle, I'm eating at regular time, it is amazing. You will be not hungry. Let's say, let's say you eat at noon. You will not feel any hunger at 11:45, and then all of a sudden the hunger jumps. This is clearly not an energy issue-

[Andrew Huberman]
Right

[Samer Hattar]
... because it could not be that drastic.

[Andrew Huberman]
Right. No, the desire to eat is mainly driven by these, uh, these cues, these hormone cues that are very exquisitely timed to-

[Samer Hattar]
Exactly

[Andrew Huberman]
... sleep-wake cycle but also to light.

[Samer Hattar]
Exactly.

[Andrew Huberman]
How regular are you, or do you recommend people be about mealtimes? Are we talking about down to the minute? Like, if I-

[Samer Hattar]
Absolutely not

[Andrew Huberman]
... all right. Plus or- so, 12 noon is my normal lunch, let's say. Uh, plus or minus?

[Samer Hattar]
Half an hour.

[Andrew Huberman]
Okay.

[Samer Hattar]
Yeah.

[Andrew Huberman]
So, eat around- between 11:30 and 12:30?

[Samer Hattar]
If, if that's the time. And it depends, if you also do multiple meals. Remember, three meals, that's decision that somebody came up with, I don't know why.

[Andrew Huberman]
Nowadays, people are- fewer people are doing that, I think.

[Samer Hattar]
Yeah. So-

[Andrew Huberman]
Gi- given our friend Satchin Panda's work.

[Samer Hattar]
Right.

[Andrew Huberman]
Right.

[Samer Hattar]
I mean, so you could have two meals, you could have very multiple s- meals that are distributed across your active time.

[Andrew Huberman]
Some people are not hungry early in the day. They might be-

[Samer Hattar]
Exactly

[Andrew Huberman]
... late shifted people.

[Samer Hattar]
Exactly.

[Andrew Huberman]
In which case, eating later in the day will, will work well for them.

[Samer Hattar]
Will work, work as long as they don't eat early in the morning. That's just, you have to work with your schedule, with your active schedule.

[Andrew Huberman]
What we're talking about really is finding your ideal sleep schedule.

[Samer Hattar]
Exactly. Exactly.

[Andrew Huberman]
And finding your ideal eating schedule.

[Samer Hattar]
Exactly.

[Andrew Huberman]
And understanding how those two things interact.

[Samer Hattar]
And, you know, the nice thing, as you said, finding them out is going to help you to understand how they interact because we know from the tripartite model that they are all interconnected. And for each person, they're going to be interconnected differently.

[Andrew Huberman]
It's striking to me that in all animals besides humans, if they deviate too much from the appropriate exposure to light and light-dark cycle, they essentially don't mate and/or die and/or get killed off. But in humans, we are able to override that at least to some extent. But the ways in which we suffer appear to be things like obesity, metabolic syndromes-

[Samer Hattar]
Yeah

[Andrew Huberman]
... uh, reproductive syndromes that are accompany the other syndromes, you know, endocrine syndromes, and mood and depressive disorders. Is there any effort at the level of the, the nationally or, or laboratories that you're aware of, to try and use light in order to improve mood and mental health?

[Samer Hattar]
I mean, honestly, this is my moonshot. This is the thing that I think people... Because it's... I, I, I say, "Don't take a pill, take a photon." Uh, not... I mean, you take pills. It's important. I'm just making it that really we have an opportunity righ- right now with the incredible advances of LED lights, of changing spectral of light, of regulating intensities. And just to assu- just for simple changes you could really improve sleep-wake cycle, productivity. And still you could actually get more done because as we've talked about, when you have all these messed up, now you have to sleep more, but your sleep is fragmented. It's not very good.

[Andrew Huberman]
And you can't focus when you're used to that.

[Samer Hattar]
And you can't focus when you don't have alertness when you need the alertness. So, having all these you... Could allow you to do even more actually at the end than less. And that's the, the exciting part of it.

[Andrew Huberman]
Let's talk about jet lag.

[Samer Hattar]
Mm-hmm.

[Andrew Huberman]
What are the two or three things that people can do to adjust their schedule quickly? Like, let's say fall classes are starting. You start a new job, or you have a baby or a puppy or whatever. What is the best way to shift the clock quickly?

[Samer Hattar]
So, it's very simple, as we've talked yesterday. So, imagine you're in, in the outside with no environmental... With no industrial light. If you, if your body thinks you're in early evening and you see a bright light, what does this tell you? "Oh, wait. This is not early evening yet. It's still early afternoon or late afternoon. So, I have to delay my clock to go back to late afternoon." So, if you get light early in the evening, it delays your clock. So, what does-

[Andrew Huberman]
Meaning that makes you want to go to sleep later?

[Samer Hattar]
Yes. It delays your clock. So, later in the night, later in your night, and actually just happens that the humans you get a temperature نديه later in the night. Temp- low temperature in your body. After that, light start advancing your clock.

[Andrew Huberman]
If I understand correctly, what you're saying is,

[Andrew Huberman]
if your typical wake-up time is, say, 7:00 AM, then your low point in temperature probably occurs somewhere around 5:00 AM?

[Samer Hattar]
Yeah.

[Andrew Huberman]
And if you view light right abou- around then, it's going to essentially advance your clock.

[Samer Hattar]
Yeah. Because then your, your body thinks, "Oh, it's seven o'clock." So, it advance your clock by one to two hours.

[Andrew Huberman]
But if I were to view light, say, at 3:00 AM, then it would probably delay my clock?

[Samer Hattar]
Yeah.

[Andrew Huberman]
Okay. Yeah. So, and then let's say I land in a new schedule. I want to adjust to a new schedule. Let's say I didn't manage to do anything with my light viewing before I went and I didn't d- I didn't anticipate the trip. Suddenly, I'm on a new schedule, okay? I was told that one of the ways to help shift the clock and to avoid gastrointestinal issues is to eat on the local schedule.

[Samer Hattar]
Mm-hmm.

[Andrew Huberman]
To start basically behaving like a local.

[Samer Hattar]
Mm-hmm.

[Andrew Huberman]
Even though your circadian clock will take a little bit of time to catch up.

[Samer Hattar]
Right. Absolutely. But, you have to remember the light, right? So, let's, let's... Now that we explained it very simply, let's take a very simple example, right? New York to Italy. That's a simple example. New York time, Italy time, six-hour difference, right? So, let's say you fly from New York at night. You reach Italy at eight o'clock in the morning. What is the time in your New York time? You... Although you reach-

[Andrew Huberman]
Six hours back.

[Samer Hattar]
Six hours back.

[Andrew Huberman]
It's 2:00 a.m. in the mor-

[Samer Hattar]
It's 2:00 AM. So, when you land Italy, you want to avoid light like the plague. Yeah, you could eat, but you really don't want to get a light.

[Andrew Huberman]
Right. 'Cause otherwise it's going to delay you.

[Samer Hattar]
It's going to delay you. It's going to send you to California instead of sending you to Italy.

[Andrew Huberman]
Right. What Samer's saying is so crucial. Just because getting bright light in your eyes early in the day is really beneficial when you're at home, when you travel to a new time zone, you have to take into account where your body thinks you are.

[Samer Hattar]
Exactly.

[Andrew Huberman]
And so if you're looking at the Italian sunrise, having just flown from New York to Italy, and you didn't prepare for that trip by waking up a little bit earlier in anticipation.

[Samer Hattar]
Multiple days, yeah.

[Andrew Huberman]
And you view light at 2:00 a.m. excuse me, at s- at 6:00 or 7:00 AM Italian time, beautiful Italian sunrise, you are going to delay your clock. You're going to basically throw yourself back to California, but you are in Italy. You're going to throw your biology back to California, and you are going to be up in the middle of the Italian night, and you're going to be uh, uh-

[Samer Hattar]
Miserable.

[Andrew Huberman]
Uh, miserable.

[Samer Hattar]
It's very important...... to avoid getting the wrong light information when you're trying to adjust your body, because otherwise it shifts you to the other, to the other cycle. Absolutely right.

[Andrew Huberman]
You are one of these people that has such vigor. I think a lot of your ability to work hard and focus and really do so many things at an impressive level is because you think about these issues and you, you think about when you're going to be optimal for focus, when you're going to be optimal for exercise, when... And the when is the key. It's-

[Samer Hattar]
Right.

[Andrew Huberman]
And I think a lot of people live in the landscape of feeling like there's something broken inside them.

[Samer Hattar]
I really agree with you that I think part of the reason I'm continuing to be able to do this that I really think about it and I make sure that I keep everything aligned. And, and that actually helps me a lot. Like, I don't suffer in sleep, I don't suffer in waking up. I never use a timer to wake up. System is so aligned it works.

[Andrew Huberman]
A lot of times people will say, "How come I go to sleep, I fall asleep fine, but then I wake up at 3:00 or 4:00 in the morning and can't fall back asleep?" Is it possible that those people were supposed to go to bed at 8:00 PM?

[Samer Hattar]
Yeah. I mean, it is possible. Uh, or it's possible that their clock is completely misaligned that they are getting maybe enough time at night when they are suppose, and then they possibly feel so sleepy in the day. So, there... All these are possible combinations.

[Andrew Huberman]
Well, that's an interesting idea I hadn't considered. So-

[Samer Hattar]
I mean, I-

[Andrew Huberman]
That what they think is their sleep, their body is so out of whack with the light-dark cycle-

[Samer Hattar]
Right

[Andrew Huberman]
... that it's actually a nap?

[Samer Hattar]
A nap or, or the weaker part of the sleep. I mean, you see this in, in when you travel to different times on before you adjust. You go to sleep really well, but two hours later, you're fully up. Two hours. If you were so tired and this is your regular sleep, there's no way you're gonna wake up in two hours.

[Andrew Huberman]
Let's talk about seasonality a little bit. Are there other effects of seasonality on humans that we are aware of?

[Samer Hattar]
Honestly, you could see it perfectly, I think, in, in Scandinavia. I mean, you could talk to people in, who live in-

[Andrew Huberman]
Sure. They get seasonal depression.

[Samer Hattar]
One, seasonal depression is one, but actually when you start asking them questions, they tell you like in the winter, they barely could wake up. They barely have the energy. Before even depression, even people who don't get seasonal depression, they'll tell you, "Our energy level is lower. Our ability to go to work is, is not the same." And in the summer, most people actually sleep very little. They tell you, "We, we really can... We, we feel like we're manic. We have all this energy." And not in a negative way, in a funny way, right? I mean, but if you want to sleep, we have to put this curtain. I think in these situations, you could really appreciate the seasonality of humans. I think we kind of destroyed our seasonality because we don't get exposed to s- that much natural light. We have all this artificial light. But I think, honestly, one of the thing that is going to happen if they follow your recommendation, this is going to cause them to also experience some changes across the season. Because now, they going to see the sun differently. If you're going to go out in the morning, in the summer, you're going to get a much bright... That's why I don't like the change in time. I know people think, "Oh, because you're biased, you..." Because I think-

[Andrew Huberman]
Wait, wait, wait, wait. Sorry, the change in time, you're talking about daylight savings?

[Samer Hattar]
Daylight saving. It's such a bad idea because it disrupts that rhythm that you're having, 'cause I think your body, if you keep that rhythm, you will see the whole seasonality. And I look at it from a different aspect than other people. If you think about it, Andrew, there is a situation where you're getting light perfectly well, and then all of a sudden they delay it by one hour because... And then even though it's the summer, your body now if you're still not adjusting, think, "Oh, wait, what happened? What kind of happened?"

[Andrew Huberman]
Well, I'm glad you're bringing this up because I always thought, you know, what's the big deal? One hour, right? One hour shift. You know, spring forward, fall back.

[Samer Hattar]
It's so hard to adjust to one hour act.

[Andrew Huberman]
But the, but this goes back to the beginning of our discussion. It's not just one hour.

[Samer Hattar]
Right.

[Andrew Huberman]
Because it's one hour across that one day.

[Samer Hattar]
Right.

[Andrew Huberman]
But there's this cumulative effect on the clock and these, uh, three elements of your-

[Samer Hattar]
Yeah

[Andrew Huberman]
... tripartite model.

[Samer Hattar]
Exactly.

[Andrew Huberman]
Like, the homeostatic, sleep, and the light-

[Samer Hattar]
Exactly

[Andrew Huberman]
... direct effects on mood.

[Samer Hattar]
And, and when it's so close, it's sometimes hard to figure out how to adjust it perfectly because, you know, we're already sleep-deprived in our society. And then you shift it by... You know? So, it, it just, it all accumulates, and it has no benefit. I just don't understand why they do this. It makes no sense.

[Andrew Huberman]
Well, I think that the reason they do it is because they don't understand the biology.

[Samer Hattar]
Exactly. Absolutely.

[Andrew Huberman]
Because one hour seems trivial unless you-

[Samer Hattar]
It's not

[Andrew Huberman]
... understand the, the repercussions of that one-hour shift. Because what's also clear now based on what you're saying is that that one-hour shift is taking you out of alignment with the natural light-dark cycle in exactly the wrong direction.

[Samer Hattar]
It's pushing people to get even later-

[Andrew Huberman]
Yeah

[Samer Hattar]
... in the summer when light is going to push you later anyway.

[Andrew Huberman]
It's really compounding the problem that already exists.

[Samer Hattar]
Exactly.

[Andrew Huberman]
Samer, this has been, um, an amazing march through the importance of light. I'm certain that people are going to start thinking about how to change their relationship with light as a way to anchor everything that they do and that's important to their health. Let's talk a little bit about where people can find you. Your laboratory is at the National Institutes of Mental Health. He is head of the chronobiology unit, all these things that I've mentioned earlier. But, um, you are active on Twitter and Instagram.

[Samer Hattar]
Right.

[Andrew Huberman]
So, what is your, uh, Twitter handle?

[Samer Hattar]
It's @samerhattar and I think the same for Instagram.

[Andrew Huberman]
Definitely give him a follow there and on, and on Twitter. And, um, and I'm sure that he'll be happy to answer questions-

[Samer Hattar]
Absolutely

[Andrew Huberman]
... uh, and ent- entertain any and all discussions about chronobiology.

[Samer Hattar]
Absolutely. Yep, and light. Yeah.

[Andrew Huberman]
Great. Thank you, Samer.

[Samer Hattar]
Awesome. Thank you, Andrew.